澳门v泥斯

史向阳



史向阳,1970年8月生,澳门v泥斯,生物科学与技术研究所教授,博士生导师,校特聘教授。2008年回国前,在美国密歇根大学历任博士后研究员、第二级副研究员、研究员和研究助理教授。美国化学会、中国化学会、中国生物材料委员会会员,上海市生物物理学会理事,北京生理科学会再生医学专业委员会秘书长、副主任委员。兼任美国密歇根大学医学和生物科学纳米技术研究所客座研究员,首届葡萄牙马德拉大学“邀请纳米技术主任(Invited Chair in Nanotechnology),Wiley-VCH期刊 Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol.副主编,美国化学会期刊 Bioconjugate Chem.编委;也是Nat. Nanotechnol.、Nat. Commun.和 J. Am. Chem. Soc.等84个国际杂志审稿人。


研究方向

1.生物纳米技术:以各种基于树状大分子或生物相容性高分子修饰或组装的多种纳米颗粒为医学平台,研究各种癌症的早期诊断、多模态诊断、治疗、联合治疗及诊疗一体化。

2.新型纳米材料和纳米复合材料的合成、组装、表面修饰、性能、及其在生物医学中的应用。

3.静电纺纳米纤维在生物医学和环境科学中的应用。

 

荣誉及获奖情况

1.2008年,获上海高校特聘教授称号;

2.2009年,入围首批SCOPUS寻找未来科学之星活动全国纳米科学前10名;

3.2010年,获首届葡萄牙马德拉大学“邀请纳米技术主任(Invited Chair in Nanotechnology)”称号;

4.2011年,获教育部“新世纪优秀人才”支持计划;

5.2013 年,获上海高校特聘教授跟踪支持计划;

6.2014年,获第五届中国侨界贡献奖创新人才奖;

7.2016年,获中国医疗保健国际交流促进会,华夏医学科技奖二等奖;

8.2017年,获上海市科技进步奖一等奖;

9.2017年,获中国纺织工业联合会教学成果奖二等奖;

10.2018年,获上海市领军人才称号;

11.2018年,获上海市自然科学奖一等奖;

12.2019年,获上海市优秀学术带头人计划。

 

主持与承担主要项目情况

1.多功能树状大分子包裹金纳米颗粒基因改造T细胞用于增强免疫治疗,科技部国家重点研发计划政府间国际科技创新合作/港澳台科技创新合作重点专项项目(立项编号:2017YFE0196200),2019.08.01-2020.12.31,项目主持人,在研。

2.利用活性聚阳离子含磷树状大分子和两亲性树冠为载体联合UTMD技术增强microRNA抑制剂的输送及其三阴性乳腺癌治疗应用,国家自然科学基金国际(地区)合作与交流项目(项目批准号:21911530230),2019.01.01-2021.12.31,项目主持人,在研。

3.智能型树状大分子纳米器件的设计及其增强肿瘤免疫治疗应用,上海市科委优秀学术带头人计划(19XD1400100),2019.05.01-2022.04.30,项目主持人,在研。

4.功能性纳米硫化铜负载的纳米凝胶的设计及其光声成像导引的肿瘤光热治疗,国家自然基金委中德科学基金研究交流中心合作研究小组项目(GZ1505),2019.01.01-2021.12.31,项目主持人,在研。

5.生物医用高分子,上海市教委上海领军人才,2019.01.01-2021.12.31,项目主持人,在研。

6.两性离子修饰的树状大分子纳米平台的构筑及其乳腺癌诊疗应用,国家自然科学基金面上项目 (项目批准号:21773026),2018.01.01-2021.12.31,项目主持人,在研。

7.有机/无机纳米杂化平台的构建及其肿瘤精准成像与治疗,国家自然科学基金国际(地区)合作与交流项目,组织间合作研究—A3前瞻计划项目(中日韩),项目批准号:81761148028,2017.08.01-2022.07.31,项目主持人,在研。

8.具有抗污性能的树状大分子纳米器件的设计及其肿瘤精准诊疗应用,上海市科委政府间国际合作项目(17540712000),2017.07.01-2020.06.30,项目主持人,在研。

9.负载抗癌药物的多功能树状大分子包裹的纳米金颗粒用于肿瘤的靶向CT诊断与治疗,教育部博士点基金(20130075110004),博导类,2014.01.01-2016.12.31,项目主持人,已结题。

10.纳米生物医用材料与技术,上海高校特聘教授跟踪计划支持, 2014.1-2016.12,项目主持人,已结题。

11.多功能杂化纳米水凝胶及其双模态分子影像学应用,中德科学基金研究交流中心项目(GZ899),2013.10-2016.9,项目主持人,已结题。

12.DENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors,葡萄牙基金委 (FCT)项目(PTDC/CTM-NAN/1748/2012), 2013.4-2015.4, 项目主持人,已结题。

13.有机/无机纳米复合修复材料及其口腔医学应用开发,国家高技术研究发展计划 (2012AA030309),2012.1-2014.12,参与,已结题。

14.利用树状大分子纳米技术构建多功能纳米杂化颗粒及其肿瘤CT/MRI双模态成像诊断研究,国家自然科学基金面上项目 (项目批准号:21273032),2013.1-2016.12,项目主持人,已结题。 

15.树状大分子纳米材料及其医学应用,教育部新世纪人才支持计划,2012.1 -2014.12,项目主持人,已结题。

16.多功能磁性氧化铁/金核壳纳米探针的构建及其分子影像诊断应用,上海市科委纳米专项(11nm0506400),2011.12 -2014. 9,项目主持人, 已结题。

17.多功能树状大分子包裹的纳米金颗粒作为平台用于癌细胞的CT成像研究,国家自然科学基金面上项目 (项目批准号:20974019),2010.1-2012.12,项目主持人,已结题。 

18.多功能树状大分子包裹的纳米金颗粒作为肿瘤CT成像造影剂的研究,上海市科委浦江人才计划(09PJ1400600),2009.7-2011.7,项目主持人,已结题。

19.基于树状大分子的多功能肿瘤成像造影剂的研究, 上海高校特聘教授奖励计划,2008.6-2011.6,项目主持人,已结题。

20.葡萄牙马德拉大学“邀请纳米技术主任”基金 (由葡萄牙科技部FCT和Santander 银行资助) ,项目主持人,2010-2018,已结题。

21.人工纳米生物机器构筑与生物医学应用的基础研究,973计划(2007CB936000),2007.7-2011.8,参与,已结题。


发表论著情况

史向阳教授的主要研究成果包括在纳米医学与生物技术、纳米科学、材料化学、高分子化学和分析化学等领域内共发表或接受发表了372篇SCI收录期刊论文,17篇书的章节和303篇会议论文、摘要或报告,并获授权发明专利84项。研究工作发表在Chem. Rev., Chem. Soc. Rev., Prog. Polym. Sci., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Adv. Sci., Small, Adv. Funct. Mater.和Biomaterials等等专业杂志上。其中影响因子超过3.0以上的文章有288篇,影响因子超过7.0以上的文章有73篇。文章总引用数超过15955次,单篇引用最高次数为486次,H-index为71。


2015年以来发表的代表论著

1.Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen*, Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21 (impact factor 10.273, citation #213).

2.Lingdan Kong, Carla S. Alves, Wenxiu Hou, Jieru Qiu, Helmuth Möhwald, Helena Tomás,* Xiangyang Shi*. RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells. ACS Appl. Mater. Interfaces 2015, 7 (8), 4833-4843 (impact factor 8.456, citation #76, ESI paper). 

3.Jia Yang, Yu Luo, Yanhong Xu, Jingchao Li, Zaixian Zhang, Han Wang, Mingwu Shen, Xiangyang Shi,* Guixiang Zhang*. Conjugation of iron oxide nanoparticles with RGD-modified dendrimers for targeted tumor MR imaging. ACS Appl. Mater. Interfaces 2015, 7(9), 5420-5428 (impact factor 8.456, citation #42). 

4.Yu Luo, He Shen, Yongxiang Fang, Yuhua Cao, Jie Huang, Mengxin Zhang, Jianwu Dai,* Xiangyang Shi,* and Zhijun Zhang*. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl. Mater. Interfaces 2015, 7 (11), 6331–6339 (impact factor 8.456, citation #160).

5.Zheng Qiao, Xiangyang Shi*. Dendrimer-based molecular imaging contrast agents. Prog. Polym. Sci. 2015, 44, 1–27 (Impact factor 24.505, citation #83).

6.Yulin Li*, Dina Maciel, João Rodrigues*, Xiangyang Shi*, Helena Tomás*. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chem. Rev. 2015, 115 (16), 8564–8608 (impact factor 54.301, citation #197).

7.Lingzhou Zhao, Jingyi Zhu, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo, Xiangyang Shi*, and Jinhua Zhao*. Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131I for SPECT Imaging and Radiotherapy of Gliomas. ACS Appl. Mater. Interfaces 2015, 7 (35), 19798–19808 (impact factor 8.456, citation #44). 

8.Hongdong Cai#, Kangan Li#, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small 2015, 11 (35), 4584-4593 (impact factor 10.856, citation #79).

9.Xin Li#, Zuogang Xiong#, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater. Interfaces 2016, 8, 19883-19891 (impact factor 8.456, citation #36). 

10.Aijun Li, Benqing Zhou, Carla S. Alves, Bei Xu, Rui Guo, Xiangyang Shi,* Xueyan Cao*. Mechanistic Studies of the Enhanced PCR Using PEGylated PEI-Entrapped Gold Nanoparticles. ACS Appl. Mater. Interfaces 2016, 8 (39), 25808–25817 (impact factor 8.456, citation #12).

11.Peng Wang#, Jia Yang#, Benqing Zhou, Yong Hu, Lingxi Xing, Fanli Xu, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*. Antifouling manganese oxide nanoparticles: Synthesis, characterization, and applications for enhanced MR imaging of tumors. ACS Appl. Mater. Interfaces 2017, 9 (1), 47-53 (impact factor 8.456, citation #19). 

12.Wenjie Sun#, Sabrina Thies#, Jiulong Zhang, Chen Peng*, Guangyu Tang, Mingwu Shen, Andrij Pich*, Xiangyang Shi*. Gadolinium-Loaded Poly(N-vinylcaprolactam) Nanogels: Synthesis, Characterization, and Application for Enhanced Tumor MR Imaging. ACS Appl. Mater. Interfaces 2017, 9 (4), 3411-3418 (impact factor 8.456, citation #28).

13.Xin Li#, Lingxi Xing#, Kailiang Zheng, Ping Wei, Lingzhou Zhao, Lianfang Du*, Mingwu Shen*, Xiangyang Shi*. Formation of Gold Nanostar-Coated Hollow Mesoporous Silica for Tumor Multi-Modality Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017, 9, 5817−5827 (impact factor 8.456, citation #66).

14.Lingdan Kong#, Lingxi Xing#, Benqing Zhou, Lianfang Du*, Xiangyang Shi*. Dendrimer-Modified MoS2 Nanoflakes as a Platform for Combinational Gene Silencing and Photothermal Therapy of Tumors. ACS Appl. Mater. Interfaces 2017, 9 (19), 15995–16005 (impact factor 8.456, citation #41).

15.Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci. 2017, 249, 374–385 (impact factor 8.243, citation #14). 

16.Lizhou Lin#, Yu Fan#, Feng Gao, Lifang Jin, Dan Li, Wenjie Sun, Fan Li, Peng Qin, Qiusheng Shi*, Xiangyang Shi*, Lianfang Du*.UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy. Theranostics 2018, 8(7), 1923-1939 (impact factor 8.063, citation #24).

17.Serge Mignani*, João Rodrigues*, Helena Tomas, Maria Zablocka, Xiangyang Shi, Anne-Marie Caminade, Jean-Pierre Majoral*. Dendrimers in combination with natural products and analogues as anti-cancer agents. Chem. Soc. Rev. 2018, 47, 514-532 (citation # 41, Impact factor 40.443).

18.Benqing Zhou#, Ruizhi Wang#, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai,* Qiang Ouyang*, Xiangyang Shi, and Mingwu Shen*. 99mTc-Labeled RGD−Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma. ACS Appl. Mater. Interfaces 2018, 10 (7), 6146–6154 (impact factor 8.456, citation #11).

19.Jean-Pierre Majoral*, Maria Zablocka*, Anne-Marie Caminade, Piotr Balczewski, Xiangyang Shi, Serge Mignani*. Interactions gold/phosphorus dendrimers. Versatile ways to hybrid organic-metallic macromolecules. Coord. Chem. Rev. 2018, 358, 80-91 (impact factor 13.476, citation #7).

20.Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*. Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev. 2018, 47, 1874-1900 (citation # 89, Impact factor 40.443).

21.Zheng Qiao, Mingwu Shen, Yunchao Xiao, Meifang Zhu, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*. Organic/inorganic nanohybrids formed using electrospun polymer nanofibers as nanoreactors. Coord. Chem. Rev. 2018, 372, 31-51 (impact factor 13.476, citation #5).

22.Jingyi Zhu#, Hongsheng Li#, Zhijuan Xiong, Mingwu Shen, Peter S. Conti, Xiangyang Shi*, Kai Chen*. Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging. ACS Appl. Mater. Interfaces 2018, 10(41), 34954-34964 (impact factor 8.456, citation #14).

23.Serge Mignani*, João Rodrigues, Helena Tomas, René Roy, Xiangyang Shi, Jean-Pierre Majoral*. Bench-to-bedside translation of dendrimers: Reality or utopia? A concise analysis. Adv. Drug Deliver. Rev. 2018, 136–137, 73–81 (impact factor 15.519, citation # 12).

24.Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci. 2018, 5, 1801612 (citation #19, Impact factor 15.804).

25.Jianzhi Zhu#, Zhicong Li#, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi*, Han Wang*, Jan C. M. van Hest*. Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy. Theranostics 2019, 9(26), 8048-8060 (impact factor 8.063, citation #0).

26.Yu Fan, Jiulong Zhang, Menghan Shi, Dan Li, Chunhua Lu, Xueyan Cao, Chen Peng*, Serge Mignani*, Jean-Pierre Majoral*, Xiangyang Shi*. PAMAM Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for Radiotherapy-Enhanced MR Imaging and Chemotherapy of Tumors and Tumor Metastasis. Nano Lett. 2019, 19, 1216−1226 (citation # 6, Impact factor 12.279).

27.Chao Cai, Xin Li, Yue Wang, Mengxue Liu, Xiangyang Shi*, Jindong Xia*, Mingwu Shen*. Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors. Chem. Eng. J. 2019, 362, 842-850 (Impact factor 8.355, citation #9).

28.Jinyuan Liu, Zhijuan Xiong, Jiulong Zhang, Chen Peng*, Barbara Klajnert-Maculewicz*, Mingwu Shen*, Xiangyang Shi*. Zwitterionic Gadolinium (III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis. ACS Appl. Mater. Interfaces 2019, 11, 15212-15221 (impact factor 8.456, citation #8).

29.Xin Li#, Shiyi Lu#, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis. Adv. Sci. 2019, 6, 1901800 (citation # 3, Impact factor 15.804).

30.Lingxi Xing#, Xin Li#, Zehua Xing#, Fan Li, Mingwu Shen, Hong Wang*, Xiangyang Shi*, Lianfang Du*. Silica/Gold Nanoplatform combined with a Thermosensitive Gel for Imaging-guided Interventional Therapy in PDX of Pancreatic Cancer. Chem. Eng. J. 2020, 382, 122949 (Impact factor 8.355, citation #0).

31.Ni Zhang, Yue Wang, Changchang Zhang, Yu Fan, Du Li, Xueyan Cao, Jindong Xia, Xiangyang Shi, Rui Guo*. LDH-Stabilized Ultrasmall Iron Oxide Nanoparticles as a Platform for Hyaluronidase-Promoted MR Imaging and Chemotherapy of Tumors. Theranostics 2020, 10, 2791-2802 (impact factor 8.063, citation #0).

32.Changchang Zhang, Wenjie Sun, Yue Wang, Fang Xu, Jiao Qu, Jindong Xia, Mingwu Shen*, Xiangyang Shi*. Gd-/CuS-Loaded Functional Nanogels for MR/PA Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Appl. Mater. Interfaces 2020, 12, 9107-9117 (impact factor 8.456, citation #0).

33.Fang Xu#, Jianzhi Zhu#, Lizhou Lin#, Changchang Zhang, Wenjie Sun, Yu Fan, Fangfang Yin, Jan C. M. van Hest, Han Wang, Lianfang Du* and Xiangyang Shi*. Redox-responsive PVCL nanogels loaded with MnO2 nanoparticles and doxorubicin for imaging-guided and UTMD-promoted chemotherapy of tumors. Theranostics 2020, 10(10), 4349-4358 (impact factor 8.063, citation #0). 

34.Ningning Song, Lingzhou Zhao, Xiaoying Xu, Meilin Zhu, Changcun Liu, Na Sun, Jiqin Yang,* Xiangyang Shi,* Jinhua Zhao*. LyP-1-modified multifunctional dendrimers for targeted anti-tumor and anti-metastasis therapy. ACS Appl. Mater. Interfaces 2020, 12, 12395-12406 (impact factor 8.456, citation #0).

35.Yu Fan#, Wenzhi Tu#, Mingwu Shen, Xuming Chen, Yuesheng Ning, Junjun Li, Tingfeng Chen, Han Wang, Fangfang Yin, Yong Liu*, Xiangyang Shi*. Targeted Tumor Hypoxia Dual Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer-Based Nanosensitizers. Adv. Funct. Mater. 2020, 30, 1909285 (impact factor 15.621, citation #0).

 

国际交流与合作

美国密歇根大学、法国国家科研中心配合物化学实验室、法国巴黎大学、德国亚琛工业大学、德国莱布尼茨聚合物研究所、荷兰埃因霍温理工大学、葡萄牙马德拉大学、匈牙利徳布勒森大学、日本大阪大学、韩国檀国大学、以色列巴伊兰大学、波兰罗茨大学。

 

主讲课程

博士研究生课程:化学前沿、纳米医学和博士生Seminar;本科生课程:纳米医学与生物技术。

 

博士后和研究生招生信息

欢迎感兴趣的具有化学、化工、生物医学、材料、纺织等相关研究背景的博士生申请博士后研究职位,同时欢迎感兴趣的具有相同背景的本科生和硕士生报考加入本课题组。

 

联系电话:021-67792656       EMAIL:xshi@dhu.edu.cn

( 更新于2020-05-02,上海)